Rifampin

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.
Rifampin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • All forms of tuberculosis.
  • Treatment of asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from the nasopharynx.

NON-FDA APPROVED USES

  • Prosthetic valve endocarditis caused by staphylococci in combination with other agents (e.g. oxacillin/nafcillin, vancomycin) after blood cultures have cleared.
  • Prosthetic joint infections following debridement and retention of the prosthesis or 1-stage exchange.
  • Meningitis caused by penicillin and ceftriaxone resistant S. pneumoniae
  • Non-tuberculous mycobacterial infections (e.g. leprosy, MAC)
  • Brucellosis
  • Bartonella infections
  • Q-fever and rickettsialinfections
  • Cutaneous leishmaniasis
  • Legionella infections
  • Anthrax infections
  • NOTE: Rifampin is usually used in combination with other agents due to quick emergence of resistance if used as monotherapy.

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INDICATIONS

FDA

  • All forms of tuberculosis.
  • Treatment of asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from the nasopharynx.

NON-FDA APPROVED USES

  • Prosthetic valve endocarditis caused by staphylococci in combination with other agents (e.g. oxacillin/nafcillin, vancomycin) after blood cultures have cleared.
  • Prosthetic joint infections following debridement and retention of the prosthesis or 1-stage exchange.
  • Meningitis caused by penicillin and ceftriaxone resistant S. pneumoniae
  • Non-tuberculous mycobacterial infections (e.g. leprosy, MAC)
  • Brucellosis
  • Bartonella infections
  • Q-fever and rickettsialinfections
  • Cutaneous leishmaniasis
  • Legionella infections
  • Anthrax infections
  • NOTE: Rifampin is usually used in combination with other agents due to quick emergence of resistance if used as monotherapy.

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