Cutibacterium (ex.Propionibacterium) species
Cutibacterium (ex.Propionibacterium) species is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- Previously termed Propionibacterium
- Major human pathogens: many species; generally the two below represent the majority of isolates. Member of Proprionibacteriaeceae.
- Cutibacterium acnes
- Cutibacterium avidum
- Major human pathogens: many species; generally the two below represent the majority of isolates. Member of Proprionibacteriaeceae.
- A Gram-positive pleomorphic rod that grows best anaerobically [Fig].
- Usually inhabits human skin, sebaceous glands, nasopharynx, GI/GU tracts.
- Generally sensitive to beta-lactams and resistant to aminoglycosides.
- Slow growth, often >5-6d.
- Incubation time may require up to 14d to recover clinically significant isolates from prosthetic joint infections, for example.
- Reclassification of Propionibacterium species as originally described due to the bacteria producing propionic acid as a fermentation product. Bacteria are seen in a wide range of conditions: including cheeses (Swiss), ruminants stomachs, human skin. Based on 16s ribosomal analysis, this is now divided into the following:
- Acidipropionibacterium gen. nov.
- Cutibacterium gen. nov.
- Pseudopropionibacterium gen. nov.
- Propionibacterium (amended description of the genus)
- Fun Fact: related P. freudenreichii is responsible for both flavor and the characteristic holes during Swiss cheese manufacture.
- C. acnes antimicrobial resistance:
- Information mainly gleaned from isolates in refractory cases of acne vulgaris, so correlation with the much less common systemic or deep infections are unclear.
- Resistance rates (approximately): erythromycin (50%), clindamycin (35%), and tetracycline (25%).
- Erythromycin and clindamycin resistance often occur in tandem.
- Tetracycline is often used if the disease breaks through erythromycin or clindamycin therapy.
- Minocycline may still have effect when either tetracycline or doxycycline-resistant strains of P. acnes are suspected.
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MICROBIOLOGY
- Previously termed Propionibacterium
- Major human pathogens: many species; generally the two below represent the majority of isolates. Member of Proprionibacteriaeceae.
- Cutibacterium acnes
- Cutibacterium avidum
- Major human pathogens: many species; generally the two below represent the majority of isolates. Member of Proprionibacteriaeceae.
- A Gram-positive pleomorphic rod that grows best anaerobically [Fig].
- Usually inhabits human skin, sebaceous glands, nasopharynx, GI/GU tracts.
- Generally sensitive to beta-lactams and resistant to aminoglycosides.
- Slow growth, often >5-6d.
- Incubation time may require up to 14d to recover clinically significant isolates from prosthetic joint infections, for example.
- Reclassification of Propionibacterium species as originally described due to the bacteria producing propionic acid as a fermentation product. Bacteria are seen in a wide range of conditions: including cheeses (Swiss), ruminants stomachs, human skin. Based on 16s ribosomal analysis, this is now divided into the following:
- Acidipropionibacterium gen. nov.
- Cutibacterium gen. nov.
- Pseudopropionibacterium gen. nov.
- Propionibacterium (amended description of the genus)
- Fun Fact: related P. freudenreichii is responsible for both flavor and the characteristic holes during Swiss cheese manufacture.
- C. acnes antimicrobial resistance:
- Information mainly gleaned from isolates in refractory cases of acne vulgaris, so correlation with the much less common systemic or deep infections are unclear.
- Resistance rates (approximately): erythromycin (50%), clindamycin (35%), and tetracycline (25%).
- Erythromycin and clindamycin resistance often occur in tandem.
- Tetracycline is often used if the disease breaks through erythromycin or clindamycin therapy.
- Minocycline may still have effect when either tetracycline or doxycycline-resistant strains of P. acnes are suspected.
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