Metronidazole

Kathryn Dzintars, Pharm.D., BCPS, Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS

Metronidazole is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

Anaerobic infections: intra-abdominal infections, skin and skin structure infections, bone and joint infections
Bacterial septicemia; endocarditis (caused by Bacteroides spp.)
Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection) in combination with agents active against Gram-negative urogenital flora.
Lower respiratory tract infections (in combination with another agent with activity against microaerophilic Streptococcus)
Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori
CNS infections (meningitis and brain abscess)
Treatment of acute intestinal amebiasis and amebic liver abscess
Treatment of symptomatic and asymptomatic trichomoniasis
Bacterial vaginosis (vaginal gel)
Acne rosacea (topical gel)

NON-FDA APPROVED USES

Colitis, including C. difficile, Crohn’s flare
Treatment of giardiasis and dracunculiasis
Periodontal disease
Elective colorectal surgery (classified as contaminated or potentially contaminated)

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INDICATIONS

FDA

Anaerobic infections: intra-abdominal infections, skin and skin structure infections, bone and joint infections
Bacterial septicemia; endocarditis (caused by Bacteroides spp.)
Gynecologic infections (endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection) in combination with agents active against Gram-negative urogenital flora.
Lower respiratory tract infections (in combination with another agent with activity against microaerophilic Streptococcus)
Adjunct treatment for gastritis and duodenal ulcer associated with Helicobacter pylori
CNS infections (meningitis and brain abscess)
Treatment of acute intestinal amebiasis and amebic liver abscess
Treatment of symptomatic and asymptomatic trichomoniasis
Bacterial vaginosis (vaginal gel)
Acne rosacea (topical gel)

NON-FDA APPROVED USES

Colitis, including C. difficile, Crohn’s flare
Treatment of giardiasis and dracunculiasis
Periodontal disease
Elective colorectal surgery (classified as contaminated or potentially contaminated)

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