Lomefloxacin

Y. Vivian Tsai, Pharm.D., Edina Avdic, Pharm.D.

INDICATIONS

Lomefloxacin has been withdrawn from the U.S. market since 1993 due to severe adverse effects, especiallyphotosensitivity.[5][6][2]
The initial FDA-approved indications included:
- Acute bacterial exacerbations of chronic bronchitis due to H.influenzae or M.catarrhalis[15][16][17]
  - Not for S.pneumoniae given high in vitro resistance.[26][10]
- Acute cystitis due to E. coli, K. pneumoniae, P. mirabilis, or S. saprophyticus[13][25]
- Complicated urinary tract infections due to E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa, C. diversus, or E. cloacae[14][9][11][8]
- Prophylaxis of transrectal prostate biopsy and transurethral surgical procedures[9][18][19]

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