Eflornithine

Paul G. Auwaerter, M.D., Edina Avdic, Pharm.D.
Pediatric Dosing Author: Taylor Imburgia, PharmD, BCPPS

INDICATIONS

FDA

  • Eflornithine (IV): no longer commercially available in the U.S.
  • Treatment of unwanted facial hair in women (topical cream)
  • High-risk neuroblastoma

NON-FDA APPROVED USES

  • African trypanosomiasis (sleeping sickness): Second-stage T. b. gambiense
    • Eflornithine is not effective against T. b. rhodesiense(East African form of the disease)
    • The drug can be obtained from the CDC by contacting the Division of Parasitic Diseases and Malaria (telephone, 404-718-4745; email, parasites@cdc.gov).
      • After hours or on weekends, call CDC’s Emergency Operations Center at 770-488-7100.

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