Daptomycin

Caitlin Soto, PharmD, BCIDP , Edina Avdic, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS

INDICATIONS

Complicated skin and skin structure infections (caused by susceptible strains of Gram-positive microorganisms, including MSSA and MRSA).
S. aureus bacteremia, including those with right-sided endocarditis, caused by MSSA and MRSA

Endocarditis caused by Enterococcus spp. resistant to vancomycin, penicillin and aminoglycosides[2]
VRE infections, including BSI, intra-abdominal infections, urinary tract infections, SSTI
Alternative therapy:
- Instead of vancomycin for left-sided native valve endocarditis caused by MSSA[2]
- S. aureus and Enterococcus spp. prosthetic joint infections
- S. aureus and Enterococcus spp. native vertebral osteomyelitis[16]
Note: daptomycin should not be used for the treatment of pneumonia

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