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- Note: for use only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated.
- Acute infections caused by Salmonella typhi
- Serious infections caused by Salmonella species, H. influenzae, specially meningeal infections, Rickettsia, Lymphogranuloma-psittacosis Chlamydia group, various Gram-negative bacteria causing bacteremia and meningitis.
- Part of a cystic fibrosis regimen when other agents are ineffective or contraindicated.
- Ocular infections (ophthalmic drops and ointments)
- Lung abscess
- Gas gangrene (in PCN allergic pts)
- Brain abscess
- Paratyphoid fever
- Q fever (Coxiella burnetii)
- Rocky mountain spotted fever and other endemic (murine or scrub) typhus infections caused by Rickettsia species
- Meningitis in PCN-allergic patients.
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