Cefepime

Paul G. Auwaerter, M.D., Kathryn Dzintars, Pharm.D., BCPS
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS

INDICATIONS

Pneumonia caused by S. pneumoniae
- Including cases associated with concurrent bacteremia, P. aeruginosa, K. pneumoniaeor Enterobacter species.
Febrile neutropenia (empiric therapy)
Uncomplicated and complicated urinary tract infections, including pyelonephritis (+/- bacteremia) caused by E. coli, K. pneumoniae, or P. mirabilis
Uncomplicated skin and skin-structure infections caused by MSSA or S. pyogenes.
Complicated intra-abdominal infections (combined with metronidazole) caused by E. coli, viridans group streptococci, P. aeruginosa, K. pneumoniae, Enterobacter species, or B. fragilis.
Active against most isolates of the following microorganisms (in vitro and clinical infections)
- Aerobic Gram-Positive Microorganisms:
  - Staphylococcus epidermidis (methicillin-susceptible isolates only)
  - Staphylococcus saprophyticus
  - Streptococcus agalactiae (Lancefield’s Group B streptococci)
- Aerobic Gram-Negative Microorganisms:
  - Acinetobacter calcoaceticus subsp. lwoffii
  - Citrobacter diversus
  - Citrobacter freundii
  - Enterobacter agglomerans
  - Haemophilus influenzae (including beta-lactamase-producing isolates)
  - Hafnia alvei
  - Klebsiella oxytoca
  - Moraxella catarrhalis (including beta-lactamase-producing isolates)
  - Morganella morganii
  - Proteus vulgaris
  - Providencia rettgeri
  - Providencia stuartii
  - Serratia marcescens

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