Bacteroides fragilis

John G. Bartlett, M.D., Valeria Fabre, M.D.

Bacteroides fragilis is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

Small, pleomorphic Gram-negative anaerobic bacillus
- Of all species, B. fragilis causes most human Bacteroides infections.
Other members of B. fragilis group include:
- Bacteroides distasonis
- Bacteroides ovatus
- Bacteroides thetaiotaomicron
- Bacteroides vulgatus
Easily grown relative to other anaerobes
Colonizes virtually all human colons
Organism possibly important in the gut for immune modulation.
B. fragilis group almost always susceptible to metronidazole, carbapenems, beta-lactam/beta-lactamase inhibitors
- Resistance rates to clindamycin, moxifloxacin, cefoxitin and cefotetan are increasing.

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MICROBIOLOGY

Small, pleomorphic Gram-negative anaerobic bacillus
- Of all species, B. fragilis causes most human Bacteroides infections.
Other members of B. fragilis group include:
- Bacteroides distasonis
- Bacteroides ovatus
- Bacteroides thetaiotaomicron
- Bacteroides vulgatus
Easily grown relative to other anaerobes
Colonizes virtually all human colons
Organism possibly important in the gut for immune modulation.
B. fragilis group almost always susceptible to metronidazole, carbapenems, beta-lactam/beta-lactamase inhibitors
- Resistance rates to clindamycin, moxifloxacin, cefoxitin and cefotetan are increasing.

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