Amikacin

Y. Vivian Tsai, Pharm.D., Kathryn Dzintars, Pharm.D., BCPS
Pediatric Dosing Author: Taylor Imburgia, PharmD, BCPPS

INDICATIONS

Amikacin sulfate is indicated in the short-term treatment of serious infections due to susceptible organisms.
- [Except uncomplicated UTI, aminoglycosides are generally used in combination for serious infections including treatment of Pseudomonas aeruginosa.]
Bacterial septicemia (including neonatal sepsis)
Respiratory tract infections
Bone and joint infections
Central nervous system infections
Skin and soft tissue infections (including burns and postoperative infections)
Intra-abdominal infections
Complicated and recurrent urinary tract infections.

Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third-/fourth-generation cephalosporin)
- Adjunctive prophylaxis with aerosolized amikacin has demonstrated some benefits in preventing ventilator-associated pneumonia in ICU patients.
- Adjunctive therapy with aerosolized amikacin has not been proven to provide additional benefits in comparison to standard-of-care intravenous therapy alone.
Tuberculosis
Non-tubercular mycobacterial (NTM) infections, MAI
Nocardia
Aerosolized amikacin has been used for the management of cystic fibrosis exacerbations.

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