Amikacin

Kathryn Dzintars, Pharm.D., BCPS
Pediatric Dosing Author: Taylor Imburgia, PharmD, BCPPS

INDICATIONS

INDICATIONS

INDICATIONS

FDA

FDA

FDA

  • Amikacin sulfate is indicated in the short-term treatment of serious infections due to susceptible organisms.
    • [Except uncomplicated UTI, aminoglycosides are generally used in combination for serious infections including treatment of Pseudomonas aeruginosa.]
  • Bacterial septicemia (including neonatal sepsis)
  • Respiratory tract infections
  • Bone and joint infections
  • Central nervous system infections
  • Skin and soft tissue infections (including burns and postoperative infections)
  • Intra-abdominal infections
  • Complicated and recurrent urinary tract infections.

NON-FDA APPROVED USES

NON-FDA APPROVED USES

NON-FDA APPROVED USES

  • Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third-/fourth-generation cephalosporin)
    • Adjunctive prophylaxis with aerosolized amikacin has demonstrated some benefits in preventing ventilator-associated pneumonia in ICU patients.
    • Adjunctive therapy with aerosolized amikacin has not been proven to provide additional benefits in comparison to standard-of-care intravenous therapy alone.
  • Tuberculosis
  • Non-tubercular mycobacterial (NTM) infections, MAI
  • Nocardia
  • Aerosolized amikacin has been used for the management of cystic fibrosis exacerbations.

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