Pronunciation:
tir-ban-i-bue-lin
Trade Name(s)
Ther. Class.
actinic ketatosis agents
Pharm. Class.
antimicrotubulars
Actinic keratosis on face or scalp.
Acts as a microtubule inhibitor; however, mechanism for effect in actinic keratosis is unknown.
Therapeutic Effect(s):
Reduction of actinic keratosis lesions.
Absorption: Negligible systemic absorption following topical use.
Distribution: Unknown.
Metabolism and Excretion: Primarily metabolized in liver via CYP3A4 isoenzyme, and to a lesser extent by CYP2C8 isoenzyme.
Half-life: Unknown.
TIME/ACTION PROFILE (plasma concentrations)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
Top | unknown | 7 hr | unknown |
Contraindicated in:
Use Cautiously in:
Derm: crusting, erosion/ulceration, erythema, flaking/scaling, swelling, vesiculation/pustulation
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Drug-Drug
None reported.
Topical (Adults): Apply sufficient amount of ointment to affected area (within a 25 cm2 contiguous area) once daily for 5 consecutive days.
Ointment: 1%
Apply sufficient amount of ointment to evenly cover up lesions on the face or scalp once daily for 5 consecutive days using 1 single-dose packet per application. Avoid application near and around the mouth and lips. Wash hands immediately with soap and water after application. Avoid washing and touching the treated area for about 8 hrs after application. After this time, area may be washed with a mild soap. Avoid transfer of ointment to the periocular area.
Reduction of actinic keratosis lesions.