Consult culture and susceptibility information, if available, and consider local epidemiology and susceptibility patterns in selecting or modifying antibacterial therapy.
Assess abdomen, bowel sounds, abdominal pain, fever, amount and frequency of diarrhea, and whether stool is bloody. Diarrhea, abdominal cramping, fever, and bloody stools should be reported to health care professional promptly as a sign of Clostridioides difficile-associated diarrhea (CDAD). May begin up to 2 or more months following cessation of therapy.
PO Administer 2 tablets twice daily in morning and evening for 3 days. Take each dose with 6–8 oz of water without regard to food. DNC: Swallow tablets whole; do not crush, break, or chew. Avoid alcohol.
Advise patient to avoid use of alcohol during therapy.
Advise patient to discontinue rifamycin if diarrhea persists more than 48 hr or worsens and to seek medical treatment for fever and/or or blood in the stools, and not to treat with antidiarrheals without consulting health care professional.
Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.