Prevention of postoperative nausea and vomiting (PONV) (as monotherapy or in combination with another antiemetic in a different pharmacologic class).
Treatment of PONV in patients who have received antiemetic prophylaxis with an agent of a different pharmacologic class or have not received prophylaxis.
Absorption: IV administration results in complete bioavailability.
Distribution: Extensively distributed to tissues.
Metabolism and Excretion: Undergoes minimal metabolism. Primarily excreted in urine (74%; 58% as unchanged drug), with 23% excreted in feces (20% as unchanged drug).
Droperidol and other QT interval prolonging medications may ↑ risk of QT interval prolongation and torsade de pointes; avoid concurrent use with droperidol.
Dopamine agonists, including levodopa, may ↓ effectiveness; avoid concurrent use.
Assess patient for nausea, vomiting, abdominal distention, and bowel sounds prior to and following administration.
Monitor ECG in patients with pre-existing arrhythmias/cardiac conduction disorders, electrolyte abnormalities, HF, patients taking other drugs or medical conditions that prolong QT interval prior to and during therapy.
IV Push: Do not dilute. Flush line prior and following injection with sterile water for injection, D5W, 0.9% NaCl, or LR. Solution is clear and colorless; do not administer solutions that are discolored or contain particulate matter. Protect from light; administer within 12 hr of removal from carton.
Instruct patient to notify health care professional immediately if they perceive a change in heart rate, feel lightheaded, or faint.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise patient to notify health care professional if pregnancy is planned or suspected. Advise breastfeeding patients to consider interrupting breastfeeding and pumping and discard breast milk for 48 hr after administration to minimize exposure to infant.