Treatment of clinically important hypotension occurring in the setting of anesthesia.
Stimulates α1, β1, and β2 receptors, leading to vasoconstriction and an increased cardiac output, both of which contribute to an increased blood pressure. Also causes indirect adrenergic stimulation by causing release of norepinephrine from sympathetic nerves.
Increased blood pressure.
Absorption: IV administration results in complete bioavailability.
Distribution: Crosses the placenta.
Metabolism and Excretion: Metabolized into norephedrine. Primarily excreted in urine.
Half-life: 6 hr.
TIME/ACTION PROFILE (blood pressure elevation)
Use Cautiously in:
CNS: dizziness, restlessness
CV: bradycardia, hypertension, palpitations, tachycardia
GI: nausea, vomiting
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
IV (Adults) 5–10 mg initially; may repeat dose as needed based on blood pressure (not to exceed maximum total dose = 50 mg).
Solution for injection (must be diluted): 50 mg/mL
Advise patient to notify health care professional if pregnant or breast feeding before surgery.
Increase in BP.
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