May ↑ levels and risk of toxicity with digoxin ; use lowest effective level of digoxin/monitor serum levels).
Route/Dosage
PO (Adults): 25 mg once daily; may be ↑ to 50 mg once daily based on need/tolerance after 8 wk.
Renal Impairment PO (Adults): CCr 15–20 mL/min– Should not exceed 25 mg/day.Hepatic Impairment PO (Adults): Moderate hepatic impairment (Child-Pugh Class B)– Should not exceed 25 mg/day.
Availability
Extended-release tablets: 25 mg, 50 mg
Assessment
Assess patient for urinary urgency, frequency, and urge incontinence periodically during therapy.
Monitor BP prior to starting and periodically during therapy; may cause ↑ BP.
Monitor for signs and symptoms of angioedema (swelling of face, lips, tongue and/or larynx). Discontinue mirabegron and treat symptomatically.
Swallow tablets whole with water; do not break, crush, or chew.
Patient/Family Teaching
Instruct patient to take mirabegron as directed. If a dose is missed, omit dose and begin taking next day; do not take 2 doses on the same day. Advise patient to read Patient Information sheet prior to starting and with each Rx refill in case of changes.
Inform patient that mirabegron may cause an increase in BP. Advise patient to have BP checked periodically during therapy.
May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
Advise patient to notify health care professional if difficulty emptying bladder occurs.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise female patients to notify health care professional if pregnancy is planned or suspected or if breast feeding.
Evaluation/Desired Outcomes
Decreased urinary frequency, urgency, and urge incontinence.
mirabegron is a sample topic from the Davis's Drug Guide.
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