5-Minute Pediatric Consult
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Reye Syndrome

Description

  • Acute encephalopathy and fatty degeneration of the liver
  • The US Centers for Disease Control and Prevention description is of an illness that meets all the following criteria:
    • Acute, noninflammatory encephalopathy that is documented clinically by (a) an alteration in consciousness and, if available, (b) a record of the CSF containing ≤8 leukocytes/mm3 or a histologic specimen demonstrating cerebral edema without perivascular or meningeal inflammation
    • Hepatopathy documented by either (a) a liver biopsy or an autopsy considered to be diagnostic of Reye syndrome or (b) a 3-fold or greater increase in the levels of the serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), or serum ammonia
    • No more reasonable explanation for the cerebral and hepatic abnormalities

Reye Syndrome has been found in 5-Minute Pediatric Consult

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